SYNTHESIS, SURFACE MODIFICATIONS AND BIOMEDICAL APPLICATIONS OF SUPER PARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONs)

Abstract

This review mainly discussed about the synthetic chemistry, functionalization of iron oxide nanoparticles with various biologically compatible molecules i.e. polymeric molecules such as PEG, PVA, gelatin, dextran, inorganic molecules such as silica, gold, gadolinium & biological molecules such as proteins, antibodies & targeting ligands & applications of these iron oxide nanoparticles in various fields such as cellular labeling, tissue repair ,drug delivery, MRI, Hyperthermia, magnetofection, detoxification of  biological fluid & removal of carbon monoxide.